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KMID : 0620920200520010001
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Experimental & Molecular Medicine
2020 Volume.52 No. 1 p.1 ~ p.1
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Apoptotic cell-derived exosomes: messages from dying cells
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Kakarla Ramesh
Hur Jae-Hark
Kim Yeon-Ji
Kim Jae-Young
Chwae Yong-Joon
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Abstract
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Apoptosis, a type of programmed cell death that plays a key role in both healthy and pathological conditions, releases extracellular vesicles such as apoptotic bodies and microvesicles, but exosome release due to apoptosis is not yet commonly accepted. Here, the reports demonstrating the presence of apoptotic exosomes and their roles in inflammation and immune responses are summarized, together with a general summary of apoptosis and extracellular vesicles. In conclusion, apoptosis is not just a ‘silent’ type of cell death but an active form of communication from dying cells to live cells through exosomes.
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KEYWORD
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Apoptosis, Cell death and immune response
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